Does hyperthyroidism predispose to thioridazine-induced hyperpyrexia and cardiac arrhythmias?

Does hyperthyroidism predispose to thioridazine-induced hyperpyrexia and cardiac arrhythmias?

Treatment with thioridazine resulted in hyperpyrexia and ventricular tachycardia in a young woman who was later shown to have thyrotoxicosis. The reasons why hyperthyroidism may enhance thioridazine toxicity are reviewed.

Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats.

OBJECTIVE In many species arrhythmias induced by myocardial ischaemia appear to be in part dependent upon cardiac sympathetic nerves. However, previous experiments in rats did not suggest that myocardial or other catecholamines are involved in ischaemic arrhythmogenesis in this species. The aim of this study was to investigate this further using transplanted hearts. METHODS We transplanted 'd...

Haematological and cardiorespiratory responses to induced hyperpyrexia.

ELEVATION of body temperature has been shown to produce altered haematological functions in both man and animals3 ,2,z,4 Heat stroke and malignant hyperpyrexia are two clinical syndromes which document these disturbances. ~,6 The syndrome of heat stroke causes haematological changes associated with exertion in an atmosphere of raised effective temperature (E.T.); temperature corrected for humid...

Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed afterdepolarization-dependent ventricular arrhythmias.

BACKGROUND In dogs, chronic complete atrioventricular block (CAVB) results in structural (biventricular hypertrophy) and electrical (delayed repolarization) remodeling, which predisposes the heart to torsade de pointes arrhythmias. We assessed the contractile alterations in the CAVB dog and tested the hypothesis that these adaptations increase delayed afterdepolarization (DAD)-dependent trigger...

Cardiac Action Potential Prolongation Induced by Isolated Thioridazine Enantiomers